The invention

Name of invention

Broadly protective live-attenuated influenza vaccine by codon usage bias

Vaccin antigrippal vivant atténué à large protection basé sur le biais d'usage des codons

Invention description

Description

This is a live-attenuated influenza vaccine with numerous silent mutations, shifting the vaccine towards avian codon usage while maintaining the same protein expression. The vaccine is attenuated in mammalian hosts and provides protection.